diff --git a/CMakeLists.txt b/CMakeLists.txt
index 07b151bccd53e02b00d528a5e8538d0895224bba..cd502e1bc634e5d54451cd46f1d88068b773e143 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -31,8 +31,8 @@ if(CMAKE_VERSION VERSION_GREATER_EQUAL "3.30.0")
 endif()
 
 set (QMEAN_VERSION_MAJOR 4)
-set (QMEAN_VERSION_MINOR 3)
-set (QMEAN_VERSION_PATCH 1)
+set (QMEAN_VERSION_MINOR 4)
+set (QMEAN_VERSION_PATCH 0)
 set (QMEAN_VERSION_STRING ${QMEAN_VERSION_MAJOR}.${QMEAN_VERSION_MINOR}.${QMEAN_VERSION_PATCH} )
 
 set(CMAKE_MODULE_PATH ${CMAKE_MODULE_PATH} ${CMAKE_SOURCE_DIR}/cmake_support)
@@ -98,7 +98,7 @@ find_package(Boost ${_BOOST_MIN_VERSION}
              REQUIRED)
 
 
-find_package(OPENSTRUCTURE 2.4.0 REQUIRED
+find_package(OPENSTRUCTURE 2.10.0 REQUIRED
              COMPONENTS mol seq seq_alg mol_alg conop db)
 
 include_directories(${Boost_INCLUDE_DIRS}
diff --git a/doc/source/conf.py b/doc/source/conf.py
index 7bc511e81aaf7d9dca61c4091a3fb6832d86d9c9..5ebe19be0a95646acbe6ca2bafdad4757c7452ef 100644
--- a/doc/source/conf.py
+++ b/doc/source/conf.py
@@ -70,9 +70,9 @@ copyright = u'2016-2020, Gabriel Studer'
 # built documents.
 #
 # The short X.Y version.
-release = '4.3.1'
+release = '4.4.0'
 # The full version, including alpha/beta/rc tags.
-release = '4.3.1'
+release = '4.4.0'
 
 # The language for content autogenerated by Sphinx. Refer to documentation
 # for a list of supported languages.