diff --git a/CHANGELOG.txt b/CHANGELOG.txt
index 751ebd634c93b21074aa3b1edb675552c6889664..36f047b5c8b05e6590b891464511acaa650115c6 100644
--- a/CHANGELOG.txt
+++ b/CHANGELOG.txt
@@ -1,4 +1,4 @@
-Changes in Release 4.X.X
+Changes in Release 4.3.0
 --------------------------------------------------------------------------------
 
 * Containerized workflows for published QMEAN flavours (QMEAN, QMEANDisCo, 
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 26944b8c187db72c72945bdcf834f1af5515260d..aea5298801bba50eae5f7c4b4c4856ad45cdea20 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -11,7 +11,7 @@ cmake_minimum_required(VERSION 3.12.1 FATAL_ERROR)
 cmake_policy(SET CMP0060 NEW)
 
 set (QMEAN_VERSION_MAJOR 4)
-set (QMEAN_VERSION_MINOR 2)
+set (QMEAN_VERSION_MINOR 3)
 set (QMEAN_VERSION_PATCH 0)
 set (QMEAN_VERSION_STRING ${QMEAN_VERSION_MAJOR}.${QMEAN_VERSION_MINOR}.${QMEAN_VERSION_PATCH} )
 
@@ -74,7 +74,7 @@ set(PYTHON_MODULE_PATH "python${Python_VERSION_MAJOR}.${Python_VERSION_MINOR}/si
 
 setup_boost()
 
-find_package(OPENSTRUCTURE 2.2.0 REQUIRED
+find_package(OPENSTRUCTURE 2.3.0 REQUIRED
              COMPONENTS mol seq seq_alg mol_alg conop db)
 
 include_directories(${Boost_INCLUDE_DIRS}
diff --git a/doc/source/conf.py b/doc/source/conf.py
index d205f2266a13beaa7b9f6221ee1a6152fc04c360..e6d7ab5a0f4858f2cc499241f160c81c5a353895 100644
--- a/doc/source/conf.py
+++ b/doc/source/conf.py
@@ -70,9 +70,9 @@ copyright = u'2016-2020, Gabriel Studer'
 # built documents.
 #
 # The short X.Y version.
-release = '4.2.0'
+release = '4.3.0'
 # The full version, including alpha/beta/rc tags.
-release = '4.2.0'
+release = '4.3.0'
 
 # The language for content autogenerated by Sphinx. Refer to documentation
 # for a list of supported languages.