diff --git a/docker/Dockerfile b/docker/Dockerfile
index 2f3e4db3d021073053e7326bff3976459b89108c..59e5b059ca4f5413a4244bd958432fbebdc83cc2 100644
--- a/docker/Dockerfile
+++ b/docker/Dockerfile
@@ -65,8 +65,7 @@ RUN cd ${SRC_FOLDER} && \
 #############
 WORKDIR /home
 ENV OST_ROOT="/usr/local"
-ENV PYTHONPATH="/usr/local/lib64/python3.10/site-packages"
-ENV LD_LIBRARY_PATH="$LD_LIBRARY_PATH:/usr/local/lib64:/usr/local/openmm/lib/"
+ENV LD_LIBRARY_PATH="$LD_LIBRARY_PATH:/usr/local/openmm/lib/"
 ENV OPENSTRUCTURE_VERSION=$OPENSTRUCTURE_VERSION
 
 ENTRYPOINT ["ost"]