diff --git a/actions/ost-compare-ligand-structures b/actions/ost-compare-ligand-structures
index bfa6b5913cbef57e5d8638a83ec0c1260ddf8e6f..2af7694d8dc02657ec953fb2fbfd13315d9db53c 100644
--- a/actions/ost-compare-ligand-structures
+++ b/actions/ost-compare-ligand-structures
@@ -250,8 +250,7 @@ def _LoadStructure(structure_path, format="auto", fault_tolerant=False):
 
     # Load the structure
     if format in ["mmcif", "cif"]:
-        entity, seqres = io.LoadMMCIF(structure_path, seqres=True,
-                                      fault_tolerant=fault_tolerant)
+        entity = io.LoadMMCIF(structure_path, fault_tolerant=fault_tolerant)
         if len(entity.residues) == 0:
             raise Exception(f"No residues found in file: {structure_path}")
     elif format == "pdb":
diff --git a/modules/io/doc/mmcif.rst b/modules/io/doc/mmcif.rst
index 203bb2961b08fd8db282a5ba5340f612b015155b..20a816d2dd4e1fb19c8f28901ef75e00c44784e0 100644
--- a/modules/io/doc/mmcif.rst
+++ b/modules/io/doc/mmcif.rst
@@ -64,9 +64,8 @@ Notes:
   It is added as string property named "pdb_auth_chain_name" to the
   :class:`~ost.mol.ChainHandle`. The mapping is also stored in
   :class:`MMCifInfo` as :meth:`~MMCifInfo.GetMMCifPDBChainTr` and
-  :meth:`~MMCifInfo.GetPDBMMCifChainTr` if SEQRES records are read in
-  :func:`~ost.io.LoadMMCIF` and a non-empty SEQRES record exists for that chain
-  (this should exclude ligands and water).
+  :meth:`~MMCifInfo.GetPDBMMCifChainTr` if a non-empty SEQRES record exists for
+  that chain (this should exclude ligands and water).
 * Molecular entities in mmCIF are identified by an ``entity.id``, which is
   extracted from ``atom_site.label_entity_id`` for the first atom of the chain.
   It is added as string property named "entity_id" to the
@@ -99,12 +98,6 @@ Information from mmCIF files that goes beyond structural data, is kept in a
 special container, the :class:`MMCifInfo` class. Here is a detailed description
 of the annotation available.
 
-.. note::
-
-  Some fields of the ``MMCifInfo`` container are only populated if SEQRES
-  records are read in :func:`~ost.io.LoadMMCIF` and a compound library is
-  available (see :func:`~ost.conop.GetDefaultLib`)
-
 .. class:: MMCifInfo
 
   This is the container for all bits of non-molecular data pulled from a mmCIF
@@ -278,9 +271,7 @@ of the annotation available.
   .. method:: GetMMCifPDBChainTr(cif_chain_id)
 
     Get the translation of a certain mmCIF chain name to the traditional PDB
-    chain name. Only works if SEQRES records are read in
-    :func:`~ost.io.LoadMMCIF` and a compound library is available (see
-    :func:`~ost.conop.GetDefaultLib`).
+    chain name.
 
     :param cif_chain_id: atom_site.label_asym_id
     :type cif_chain_id: :class:`str`
@@ -298,8 +289,6 @@ of the annotation available.
   .. method:: GetPDBMMCifChainTr(pdb_chain_id)
 
     Get the translation of a certain PDB chain name to the mmCIF chain name.
-    Only works if SEQRES records are read in :func:`~ost.io.LoadMMCIF` and a
-    compound library is available (see :func:`~ost.conop.GetDefaultLib`).
 
     :param pdb_chain_id: atom_site.auth_asym_id
     :type pdb_chain_id: :class:`str`
diff --git a/modules/mol/alg/pymod/ligand_scoring.py b/modules/mol/alg/pymod/ligand_scoring.py
index 00d2365db7288deab75e568475d51b095e76f1d3..bd305432f48f025ec24c21770a07ff8d190610e5 100644
--- a/modules/mol/alg/pymod/ligand_scoring.py
+++ b/modules/mol/alg/pymod/ligand_scoring.py
@@ -111,7 +111,7 @@ class LigandScorer:
         # Ligand model as SDF file
         model_ligand = io.LoadEntity("path_to_ligand.sdf", format="sdf")
         # Target loaded from mmCIF, containing the ligand
-        target, _ = io.LoadMMCIF("path_to_target.cif", seqres=True)
+        target = io.LoadMMCIF("path_to_target.cif")
 
         # Cleanup a copy of the structures
         cleaned_model = model.Copy()
diff --git a/modules/mol/alg/tests/test_ligand_scoring.py b/modules/mol/alg/tests/test_ligand_scoring.py
index 61f70d8b4507d631759541dc6c2256f1c6e54f77..3adeaf5f92afe2f6eb8e8d3ff8ebf5f326bff414 100644
--- a/modules/mol/alg/tests/test_ligand_scoring.py
+++ b/modules/mol/alg/tests/test_ligand_scoring.py
@@ -22,7 +22,7 @@ def _GetTestfilePath(filename):
 @lru_cache(maxsize=None)
 def _LoadMMCIF(filename):
     path = _GetTestfilePath(filename)
-    ent, seqres = io.LoadMMCIF(path, seqres=True)
+    ent = io.LoadMMCIF(path)
     return ent
 
 
diff --git a/modules/mol/base/doc/entity.rst b/modules/mol/base/doc/entity.rst
index 657125a2fa11c289dcfb3339d22cfdae4ccd561a..795c9b7c2674fd0bb1835a08186fe407bca947ce 100644
--- a/modules/mol/base/doc/entity.rst
+++ b/modules/mol/base/doc/entity.rst
@@ -741,11 +741,6 @@ The Handle Classes
   
   .. attribute:: is_ligand
 
-    .. warning::
-      This property is meaningless on mmCIF files loaded with
-      :func:`ost.io.LoadMMCIF` with `seqres=False` (the default), or if no
-      default compound library is set.
-
     Whether the residue is a ligand. When loading PDB structures, this property
     is set based on the HET records. This also means, that this property will
     most likely not be set properly for all except PDB files coming from