diff --git a/README.md b/README.md index 9a476fbd5e42bc3a440e48bbd27ae32c957b880a..3dcc2e52217c8d6ebfbfcd8e92a60ae83bd148bd 100644 --- a/README.md +++ b/README.md @@ -11,12 +11,13 @@ Inputs to the simuation: 1. Csv-formatted table “GeneID,Counts” specifying the number of transcripts expressed, on average, for each gene in a given cell type. These can come for example from a bulk RNA-seq experiment of sorted cells of a given type. 2. File with the genome sequence 3. gff/gtf-formatted file with the transcript annotation of the genome -4. Number of reads to sequence -5. Number of cells to simulate -6. Mean and standard deviation of RNA fragment length -7. Read length -8. Probability of intron inclusion - considered constant per intron to start with, can be extended to intron-specific. In the latter case, estimates could be obtained from bulk RNA-seq data by dividing the average per-position coverage in a given intron by the average per-position coverage of the gene, or of flanking exons. -9. Option to add poly(A) tails to transcripts and an associated function for generating these tails (with specific length distribution and non-A nucleotide frequency). -10. Parameters for evaluating internal priming: primer sequence, function implementing the constraints on priming sites (accessibility, energy of interaction, perfect matching at last primer position etc.). +4. Output directory +5. Number of reads to sequence +6. Number of cells to simulate +7. Mean and standard deviation of RNA fragment length +8. Read length +9. Probability of intron inclusion - considered constant per intron to start with, can be extended to intron-specific. In the latter case, estimates could be obtained from bulk RNA-seq data by dividing the average per-position coverage in a given intron by the average per-position coverage of the gene, or of flanking exons. +10. Option to add poly(A) tails to transcripts and an associated function for generating these tails (with specific length distribution and non-A nucleotide frequency). +11. Parameters for evaluating internal priming: primer sequence, function implementing the constraints on priming sites (accessibility, energy of interaction, perfect matching at last primer position etc.).