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  1. Jun 12, 2024
    • Studer Gabriel's avatar
      enable pairwise sequence alignments with parasail · adb141f9
      Studer Gabriel authored
      Parasail: https://github.com/jeffdaily/parasail
      
      It's faster than the pairwise sequence algorithms we have in
      OpenStructure. However, the main reason to check out another solution
      is the fact that OpenStructure may return suboptimal alignment
      results. This is a result of how the dynamic programming table is built.
      If for a certain cell in the dynamic programming table a match state and
      insertion state score equally, match is preferred. There is a chance
      that we would get a better score later on if we would stick with the
      insertion state (gap open penalties vs. gap extension penalties).
      Not sure if this will be fixed in the near future.
      adb141f9
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